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Matt Wheeler
Associate
Patents and Innovations
San Diego
mwheeler@wsgr.com

D858-350-2317

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Dr. Matt Wheeler is an associate in the patents and innovations practice group in Wilson Sonsini Goodrich & Rosati’s San Diego office, where he provides strategic patent counseling to clients on a wide variety of technologies. Matt’s scientific expertise includes antibodies, biologics, diagnostics, and medical devices.

Matt works with clients at all stages, from start-ups to public companies, to develop and implement global patent strategies. His counseling experience includes freedom to operate analysis; due diligence for mergers and acquisitions, private financings, and public markets; and all stages of preparation and prosecution of patent filings in the U.S. and around the world, including post-grant procedures.

Matt first joined Wilson Sonsini as a patent agent in 2014 and transitioned to an associate role after attending law school at the University of San Diego.

Prior to joining the firm, Matt obtained his Ph.D. in biomedical sciences from UC San Diego, where he studied immunology and antibody engineering. After receiving his Ph.D., Matt conducted postdoctoral studies at The Scripps Research Institute where he studied the role ER stress plays in inflammation and metabolic diseases.

Experience

Dr. Matt Wheeler is an associate in the patents and innovations practice group in Wilson Sonsini Goodrich & Rosati’s San Diego office, where he provides strategic patent counseling to clients on a wide variety of technologies. Matt’s scientific expertise includes antibodies, biologics, diagnostics, and medical devices.

Matt works with clients at all stages, from start-ups to public companies, to develop and implement global patent strategies. His counseling experience includes freedom to operate analysis; due diligence for mergers and acquisitions, private financings, and public markets; and all stages of preparation and prosecution of patent filings in the U.S. and around the world, including post-grant procedures.

Matt first joined Wilson Sonsini as a patent agent in 2014 and transitioned to an associate role after attending law school at the University of San Diego.

Prior to joining the firm, Matt obtained his Ph.D. in biomedical sciences from UC San Diego, where he studied immunology and antibody engineering. After receiving his Ph.D., Matt conducted postdoctoral studies at The Scripps Research Institute where he studied the role ER stress plays in inflammation and metabolic diseases.

Education
  • J.D., University of San DiegoMagna Cum Laude, Order of the Coif
  • Ph.D., Biomedical Sciences, University of California, San Diego
  • B.S., Biological Sciences, University of Missouri
Associations and Memberships
  • San Diego Intellectual Property Law Association
Admissions
  • State Bar of California
  • U.S. Patent and Trademark Office
Credentials
Education
  • J.D., University of San DiegoMagna Cum Laude, Order of the Coif
  • Ph.D., Biomedical Sciences, University of California, San Diego
  • B.S., Biological Sciences, University of Missouri
Associations and Memberships
  • San Diego Intellectual Property Law Association
Admissions
  • State Bar of California
  • U.S. Patent and Trademark Office

Select Publications

  • Co-author with J. Pitman, D. Lloyd, R. Glynne, J. Walker, and N. Gekakis, "Jack Lalanne, a gain-of-function mutation in mouse adenylate cyclase 3 that protects against diet-induced obesity," 9(10) PLoS ONE e110226, October 2014
  • Co-author with N. Gekakis, "Hsp90 modifies Ppar? activity in a mouse model of non-alcoholic fatty liver disease," 55(8) Journal of Lipid Research 1702-1710, June 2014
  • Co-author with Y. Prabhu, E.H. Blanco, M. Liiu, JR. Peinado, N. Gekakis, P. Arvan, and I. Lidberg, "Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function," 155(7) Endocrinology 2391-2401, May 2014
  • Co-author with N. Gekakis, "Defective ER Associated Degradation of a Model Luminal Substrate in Yeast Carrying a Mutation in the 4th ER Luminal Loop of Sec61p.," 427(4) Biochemical and Biophysical Research Communications 768-73, November 2012
  • Co-author with D. Lloyd and N. Gekakis, "A Point Mutation in Sec61a1 Leads to Diabetes and Hepatosteatosis in Mice," 59(2) Diabetes 460-70, February 2012
  • Co-author with N. Mahadevan, J. Rodvold, G. Almanza, A. Fernandez, and M. Zanetti, "ER stress drives Lipocalin 2 transcription in prostate cancer cells in an NF-kB-dependent manner," 11(1) BMC Cancer 229, June 2011
  • Co-author with A. Franco, G. Almanza, J.C. Burns, and M. Zanetti, "Endoplasmic reticulum Stress Drives a Regulatory Phenotype in Human T-Cell Clones," 266(1) Cell Immunology 1-6, September 2010
  • Co-author with M. Rizzi, R. Sasik, G. Almanza, G. Hardiman, and M. Zanetti, "KDEL retained Antigen in B Lymphocytes Induces a Pro-inflammatory Response: A Possible Role for ER Stress in Adaptive T cell Immunity," 181(1) Journal of Immunology 256-64, July 2008
  • Co-author with X. Cortez-Gonzalez, R. Frazzi, and M. Zanetti, "Mechanisms of Internalization and Activation by Plasmid DNA in B lymphocytes," 25(3-4) International Reviews of Immunology, May-August 2006
  • Co-author with X. Cortez-Gonzalez, I. Pellicciotta, M. Gerloni, P. Castiglioni, P. Lenert, and M. Zanetti, "TLR9 Independent Activation of B Lymphocytes by Bacterial DNA," 25(5) DNA Cell Biology 253-61, May 2006
  • Co-author with M. Rizzi, M. Gerloni, A.S. Sirvastava, K. Schuler, E. Carrier, and M. Zanetti, "In utero DNA immunisation. Immunity over tolerance in fetal life," 23(33) Vaccine 4273-82. July 2005
  • Co-author with M. Zanetti, P. Castiglioni, and M. Rizzi, "B lymphocytes as antigen-presenting cell-based genetic vaccines," 199 Immunology Reviews 264-78, June 2004
  • Co-author with G. Filcai, M. Gerloni, M. Rizzi, M. Castiglioni, H.D. Ghang, R. Fiocca, and M. Zanetti, "Spontaneous transgenesis of human B lymphocytes," 11(1) Gene Therapy 42-51, January 2004
Insights

Select Publications

  • Co-author with J. Pitman, D. Lloyd, R. Glynne, J. Walker, and N. Gekakis, "Jack Lalanne, a gain-of-function mutation in mouse adenylate cyclase 3 that protects against diet-induced obesity," 9(10) PLoS ONE e110226, October 2014
  • Co-author with N. Gekakis, "Hsp90 modifies Ppar? activity in a mouse model of non-alcoholic fatty liver disease," 55(8) Journal of Lipid Research 1702-1710, June 2014
  • Co-author with Y. Prabhu, E.H. Blanco, M. Liiu, JR. Peinado, N. Gekakis, P. Arvan, and I. Lidberg, "Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function," 155(7) Endocrinology 2391-2401, May 2014
  • Co-author with N. Gekakis, "Defective ER Associated Degradation of a Model Luminal Substrate in Yeast Carrying a Mutation in the 4th ER Luminal Loop of Sec61p.," 427(4) Biochemical and Biophysical Research Communications 768-73, November 2012
  • Co-author with D. Lloyd and N. Gekakis, "A Point Mutation in Sec61a1 Leads to Diabetes and Hepatosteatosis in Mice," 59(2) Diabetes 460-70, February 2012
  • Co-author with N. Mahadevan, J. Rodvold, G. Almanza, A. Fernandez, and M. Zanetti, "ER stress drives Lipocalin 2 transcription in prostate cancer cells in an NF-kB-dependent manner," 11(1) BMC Cancer 229, June 2011
  • Co-author with A. Franco, G. Almanza, J.C. Burns, and M. Zanetti, "Endoplasmic reticulum Stress Drives a Regulatory Phenotype in Human T-Cell Clones," 266(1) Cell Immunology 1-6, September 2010
  • Co-author with M. Rizzi, R. Sasik, G. Almanza, G. Hardiman, and M. Zanetti, "KDEL retained Antigen in B Lymphocytes Induces a Pro-inflammatory Response: A Possible Role for ER Stress in Adaptive T cell Immunity," 181(1) Journal of Immunology 256-64, July 2008
  • Co-author with X. Cortez-Gonzalez, R. Frazzi, and M. Zanetti, "Mechanisms of Internalization and Activation by Plasmid DNA in B lymphocytes," 25(3-4) International Reviews of Immunology, May-August 2006
  • Co-author with X. Cortez-Gonzalez, I. Pellicciotta, M. Gerloni, P. Castiglioni, P. Lenert, and M. Zanetti, "TLR9 Independent Activation of B Lymphocytes by Bacterial DNA," 25(5) DNA Cell Biology 253-61, May 2006
  • Co-author with M. Rizzi, M. Gerloni, A.S. Sirvastava, K. Schuler, E. Carrier, and M. Zanetti, "In utero DNA immunisation. Immunity over tolerance in fetal life," 23(33) Vaccine 4273-82. July 2005
  • Co-author with M. Zanetti, P. Castiglioni, and M. Rizzi, "B lymphocytes as antigen-presenting cell-based genetic vaccines," 199 Immunology Reviews 264-78, June 2004
  • Co-author with G. Filcai, M. Gerloni, M. Rizzi, M. Castiglioni, H.D. Ghang, R. Fiocca, and M. Zanetti, "Spontaneous transgenesis of human B lymphocytes," 11(1) Gene Therapy 42-51, January 2004

Biological Sciences and Biotechnology

  • Antibody
  • Antigen presentation
  • Biochemical assays
  • Biologics
  • Cancer biology
  • Cancer therapeutics
  • CAR-T cells
  • Cell biology
  • Cell culture products
  • Cell therapy
  • Cellular biology
  • Cellular immunology
  • Host-pathogen interactions
  • Immuno-oncology
  • Immunobiology
  • Immunology
  • Molecular biology
  • PCR
  • T and B cell biology
  • T cell biology
  • T cell immunology
  • Virology

Therapeutics and Drug Discovery

  • Biosimilars
  • Drug conjugates
  • Drug conjugates based drug discovery
  • Drug delivery
  • Immunotherapy targets
  • Peptide therapeutics
  • Pharmacodynamics
  • Pharmacogenomics
  • Pharmacokinetics
  • Vaccines

Diagnostics and Medical Devices

  • Diagnostics

Miscellaneous

  • COVID 19
  • Infectious diseases
  • Physiology
Technical Fluency

Biological Sciences and Biotechnology

  • Antibody
  • Antigen presentation
  • Biochemical assays
  • Biologics
  • Cancer biology
  • Cancer therapeutics
  • CAR-T cells
  • Cell biology
  • Cell culture products
  • Cell therapy
  • Cellular biology
  • Cellular immunology
  • Host-pathogen interactions
  • Immuno-oncology
  • Immunobiology
  • Immunology
  • Molecular biology
  • PCR
  • T and B cell biology
  • T cell biology
  • T cell immunology
  • Virology

Therapeutics and Drug Discovery

  • Biosimilars
  • Drug conjugates
  • Drug conjugates based drug discovery
  • Drug delivery
  • Immunotherapy targets
  • Peptide therapeutics
  • Pharmacodynamics
  • Pharmacogenomics
  • Pharmacokinetics
  • Vaccines

Diagnostics and Medical Devices

  • Diagnostics

Miscellaneous

  • COVID 19
  • Infectious diseases
  • Physiology
Focus Areas
  • Intellectual Property
  • Life Sciences
  • Patents and Innovations
Recent Insights
Client Highlights
Wilson Sonsini Advises Odyssey Therapeutics on Patent Matters Related to IPO
On May 7, 2026, Odyssey Therapeutics, a clinical-stage biopharmaceutical company seeking to transform the standard of care for patients suffering from autoimmune and inflammatory diseases by developing medicines that are designed to precisely target disease pathology, announced the pricing of its upsized initial public offering of 15,500,000 shares of its common stock at an initial public offering price of $18.00 per share. In addition, Odyssey has granted the underwriters a 30-day option to purchase up to an additional 2,325,000 shares of common stock at the initial public offering price, less underwriting discounts and commissions. Odyssey’s common stock began trading on the Nasdaq Capital Market on May 8, 2026, under the ticker symbol “ODTX.” The offering closed on May 11, 2026. Wilson Sonsini Goodrich & Rosati advised Odyssey on patent matters related to the transaction.
Learn More
Client Highlights
Wilson Sonsini Advises ImmunityBio on Execution of $80 Million Equity Financing
On July 25, 2025, ImmunityBio, a biotechnology company developing therapies that bolster the natural immune system to defeat cancers and infectious diseases, announced it has executed financing to provide further working capital and support its ongoing business operations. The company entered into a securities purchase agreement for a registered direct offering with two institutional investors, providing for the issuance of common stock of ImmunityBio as well as warrants for the purchase of additional shares of common stock of ImmunityBio that is expected to result in gross proceeds at closing of approximately $80 million before deducting placement agent fees and other offering-related expenses, subject to customary closing conditions. If fully exercised, the warrants could result in additional gross proceeds of up to approximately $96 million. Wilson Sonsini Goodrich & Rosati advised ImmunityBio on the transaction.
 
The Wilson Sonsini team advising ImmunityBio includes:
 
Corporate 
Marty Waters
Ben Capps
David Sharon
Michael Brito-Stamm
Brandon Shaw
James Keegan
 
Patents and Innovations
Matt Bresnahan
Matt Wheeler
Yingchun Ni
 
For more information, please see ImmunityBio’s press release.
Learn More
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