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Joseph E. Lesniewski
Associate
Patents and Innovations
Washington, D.C.
jlesniewski@wsgr.com

D202-920-8734

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Dr. Joseph E. Lesniewski (Joe) is an associate in the Washington, D.C., office of Wilson Sonsini Goodrich & Rosati, where he is a member of the patents and innovations practice. He has extensive interdisciplinary technical expertise that spans across the fields of physical chemistry, organic chemistry, inorganic chemistry, analytical chemistry, computer science, and mechanical and electrical engineering.

Joe earned his Ph.D. in chemistry from Georgetown University, where his doctoral research focused on designing new ion sources and chemical instrumentation for efficient detection and quantitation of nonmetal elements by elemental mass spectrometry. His research was applied towards pharmaceutical development and trace analysis of contaminants in complex sample matrices.

Joe has also conducted research at the National Institute of Standards and Technology (NIST), where he focused on development of an automation software package for refinement of magnetic and nonmagnetic crystal structures from neutron and x-ray diffraction patterns using high-performance computing clusters.

Prior to joining the firm, Joe was an intellectual property and commercialization intern at Georgetown University’s Office of Technology Commercialization, where he gained experience marketing technologies to potential licensees and working with patent applications from a variety of fields including small molecules, medical devices, energy technologies, and computer science technologies.

Joe is an inventor on U.S. Patent No. 12,322,584.

Experience

Dr. Joseph E. Lesniewski (Joe) is an associate in the Washington, D.C., office of Wilson Sonsini Goodrich & Rosati, where he is a member of the patents and innovations practice. He has extensive interdisciplinary technical expertise that spans across the fields of physical chemistry, organic chemistry, inorganic chemistry, analytical chemistry, computer science, and mechanical and electrical engineering.

Joe earned his Ph.D. in chemistry from Georgetown University, where his doctoral research focused on designing new ion sources and chemical instrumentation for efficient detection and quantitation of nonmetal elements by elemental mass spectrometry. His research was applied towards pharmaceutical development and trace analysis of contaminants in complex sample matrices.

Joe has also conducted research at the National Institute of Standards and Technology (NIST), where he focused on development of an automation software package for refinement of magnetic and nonmagnetic crystal structures from neutron and x-ray diffraction patterns using high-performance computing clusters.

Prior to joining the firm, Joe was an intellectual property and commercialization intern at Georgetown University’s Office of Technology Commercialization, where he gained experience marketing technologies to potential licensees and working with patent applications from a variety of fields including small molecules, medical devices, energy technologies, and computer science technologies.

Joe is an inventor on U.S. Patent No. 12,322,584.

Education
  • J.D., American University Washington College of Law, 2024
  • Ph.D., Chemistry, Georgetown University, 2021
  • M.S., Chemistry, Georgetown University, 2018
  • B.S., Chemistry, Mount St. Mary’s University, 2015

    Minor in Computer Science

Admissions
  • Bar of the District of Columbia
  • U.S. Patent and Trademark Office
Credentials
Education
  • J.D., American University Washington College of Law, 2024
  • Ph.D., Chemistry, Georgetown University, 2021
  • M.S., Chemistry, Georgetown University, 2018
  • B.S., Chemistry, Mount St. Mary’s University, 2015

    Minor in Computer Science

Admissions
  • Bar of the District of Columbia
  • U.S. Patent and Trademark Office

Select Publications

  • Co-author with F. Redeker, G. Hahm, W. McMahon, and K. Jorabchi, "High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds," 94(34) Analytical Chemistry 11865-11872, 2022
  • Co-author with S. White, K. Zheng, J. Tanen, and K. Jorabchi, "Elemental detection of fluorochemicals by nanospray-induced chemical ionization in afterglow of an inductively coupled plasma," 37(4) Journal of Analytical Atomic Spectrometry 870-882, 2022
  • Co-author with K. Zheng, M. Dolan Jr., W. Li, T. Metallo, and K. Jorabchi, "Elemental fluorine detection by dielectric barrier discharge coupled to nano-ESI mass spectrometry for nontargeted analysis of fluorinated compounds," 92(14) Analytical Chemistry 10129-10137, 2020
  • Co-author with W. McMahon, R. Dalvi, Z. Hall, and K. Jorabchi, "Pulsed Nano-ESI: Application in Ion Mobility-MS and Insights into Spray Dynamics," 31(3) Journal of the American Society for Mass Spectrometry 488-497, 2020
  • Co-author with K. Zheng, P. Lecchi, D. Dain, and K. Jorabchi, "High-sensitivity elemental mass spectrometry of fluorine by ionization in plasma afterglow," 91(6) Analytical Chemistry 3773-3777, 2019
  • Co-author with W. McMahon and K. Jorabchi, "Mechanistic insights into chloride ion detection from the atmospheric-pressure afterglow of an argon inductively coupled plasma," 33(11) Journal of Analytical Atomic Spectrometry 1981–1992, 2018
  • Co-author with W. McMahon, K. Zheng, H. Wang, H. Badiei, and K. Jorabchi, "Atmospheric pressure plasma assisted reaction chemical ionization for analysis of chlorinated compounds separated by liquid chromatography," 32(9) Journal of Analytical Atomic Spectrometry 1757–1765, 2017
  • Co-author with S. Disseler, D. Quintana, P. Kienzle, and W. Ratcliff, "Bayesian method for the analysis of diffraction patterns using BLAND," 49(6) Journal of Applied Crystallography 2201-2209, 2016

Select Speaking Engagements

  • Speaker, "Elemental mass spectrometry of fluorine: challenges and innovations in ionization and detection," SciX 2019, Palm Springs, California, October 2019
Insights

Select Publications

  • Co-author with F. Redeker, G. Hahm, W. McMahon, and K. Jorabchi, "High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds," 94(34) Analytical Chemistry 11865-11872, 2022
  • Co-author with S. White, K. Zheng, J. Tanen, and K. Jorabchi, "Elemental detection of fluorochemicals by nanospray-induced chemical ionization in afterglow of an inductively coupled plasma," 37(4) Journal of Analytical Atomic Spectrometry 870-882, 2022
  • Co-author with K. Zheng, M. Dolan Jr., W. Li, T. Metallo, and K. Jorabchi, "Elemental fluorine detection by dielectric barrier discharge coupled to nano-ESI mass spectrometry for nontargeted analysis of fluorinated compounds," 92(14) Analytical Chemistry 10129-10137, 2020
  • Co-author with W. McMahon, R. Dalvi, Z. Hall, and K. Jorabchi, "Pulsed Nano-ESI: Application in Ion Mobility-MS and Insights into Spray Dynamics," 31(3) Journal of the American Society for Mass Spectrometry 488-497, 2020
  • Co-author with K. Zheng, P. Lecchi, D. Dain, and K. Jorabchi, "High-sensitivity elemental mass spectrometry of fluorine by ionization in plasma afterglow," 91(6) Analytical Chemistry 3773-3777, 2019
  • Co-author with W. McMahon and K. Jorabchi, "Mechanistic insights into chloride ion detection from the atmospheric-pressure afterglow of an argon inductively coupled plasma," 33(11) Journal of Analytical Atomic Spectrometry 1981–1992, 2018
  • Co-author with W. McMahon, K. Zheng, H. Wang, H. Badiei, and K. Jorabchi, "Atmospheric pressure plasma assisted reaction chemical ionization for analysis of chlorinated compounds separated by liquid chromatography," 32(9) Journal of Analytical Atomic Spectrometry 1757–1765, 2017
  • Co-author with S. Disseler, D. Quintana, P. Kienzle, and W. Ratcliff, "Bayesian method for the analysis of diffraction patterns using BLAND," 49(6) Journal of Applied Crystallography 2201-2209, 2016

Select Speaking Engagements

  • Speaker, "Elemental mass spectrometry of fluorine: challenges and innovations in ionization and detection," SciX 2019, Palm Springs, California, October 2019

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Technical Fluency

Biological Sciences and Biotechnology

  • Biochemical assays
  • Biochemistry
  • Bioconjugation
  • Biophysics
  • Cancer therapeutics
  • Glycobiology
  • Metabolomics
  • Microbiology
  • Molecular biology

Therapeutics and Drug Discovery

  • Antimicrobial agents
  • Biosimilars
  • Drug conjugates
  • Drug conjugates based drug discovery
  • Drug delivery
  • Immunotherapy targets
  • Neuropharmacology
  • Pharmacodynamics
  • Pharmacokinetics
  • Pharmacology
  • Small molecule synthesis
  • Small molecules

Diagnostics and Medical Devices

  • Bioinformatic
  • Biomedical devices
  • Biomedical engineering
  • Biosensors
  • Diagnostics
  • Digital pathology
  • Medical devices
  • Medical imaging
  • Neuroimaging
  • Point-of-care testing (POCT)
  • Telemedicine technology
  • Wearable analyte sensors

Chemistry and Material Science

  • Catalysis
  • Chemical synthesis
  • Chemistry
  • Chemoenzymatic synthesis
  • Green chemistry
  • Materials chemistry
  • Nanochemistry
  • Organic chemistry
  • Organometallics
  • Photovoltaic materials
  • Polymers
  • Polymorph
  • Process chemistry
  • Supramolecular chemistry

Engineering and Technology

  • 3D bioprinting
  • AI
  • Biomechanics
  • Computer science
  • Electrical engineering
  • Machine learning
  • Materials science
  • Mechanical engineering
  • Microfluidics
  • Robotics

Genomics and Data Analysis

  • Bioinformatics algorithms
  • Computational biology

Miscellaneous

  • Design patent
  • Engineered foods
  • Fluorescence microscopy
  • Food science
  • Formulations
  • Litigation/PTAB/Oppositions
  • Ophthalmology
  • Physical therapy
  • Physics
  • Physiology
Focus Areas
  • Intellectual Property
  • Life Sciences
  • Patents and Innovations
Recent Insights
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Firm Advises Matterworks on IP and Patent Matters Related to Series A Financing
On June 3, 2025, Matterworks, Inc., the category-defining pioneer unlocking unstructured molecular data for predictive biology, announced a new Series A financing. The round was led by Lewis & Clark Partners and OMX Ventures and joined by Pillar VC, Germin8 Ventures, Intermountain Ventures, and Tarsadia, among others. Matterworks will use the Series A proceeds to grow its model as a service (MaaS) business and expand its machine learning and scientific operations. For example, Matterworks' Large Spectral Models (LSMs) productize self-supervised machine intelligence for direct machine interpretation of molecular-omic data. The company’s PyxisTMproduct, released in 2024, is the first generative AI for complete untargeted molecular annotation, unlocking new data modalities for understanding and predicting complex biological outcomes.
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Wilson Sonsini Advises on Patent Matters Related to Verona’s FDA Approval
On June 26, 2024, Verona Pharma announced that the U.S. Food and Drug Administration approved Ohtuvayre (ensifentrine) for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adult patients. Ohtuvayre is the first inhaled product with a novel mechanism of action available for the maintenance treatment of COPD in more than 20 years. Wilson Sonsini Goodrich & Rosati advised Verona Pharma on patent matters.
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