Dr. Tyler Baguley is a patent counselor in the San Diego office of Wilson Sonsini Goodrich & Rosati. He assists with the preparation and prosecution of patent applications in the fields of chemistry, pharmaceuticals, and biotechnology.
Prior to joining the firm, Tyler was a postdoctoral fellow on the medicinal chemistry team at the California Institute for Biomedical Research in La Jolla. In this role, he focused on the design and synthesis of organic small molecules to treat a variety of disease indications such as diabetes, fibrosis, and infectious disease. During his doctoral studies at the University of California, Berkeley, he developed inhibitors of protein tyrosine phosphatases, as well as new synthetic methodologies. He has co-authored several scientific publications and is a co-inventor on three U.S. patent applications.
Dr. Tyler Baguley is a patent counselor in the San Diego office of Wilson Sonsini Goodrich & Rosati. He assists with the preparation and prosecution of patent applications in the fields of chemistry, pharmaceuticals, and biotechnology.
Prior to joining the firm, Tyler was a postdoctoral fellow on the medicinal chemistry team at the California Institute for Biomedical Research in La Jolla. In this role, he focused on the design and synthesis of organic small molecules to treat a variety of disease indications such as diabetes, fibrosis, and infectious disease. During his doctoral studies at the University of California, Berkeley, he developed inhibitors of protein tyrosine phosphatases, as well as new synthetic methodologies. He has co-authored several scientific publications and is a co-inventor on three U.S. patent applications.
- Ph.D., Chemistry, University of California, Berkeley, 2014
- B.S., Biochemistry, University of Oregon, 2008Summa Cum Laude; Departmental Honors; Recipient, 2008 Organic Chemistry Achievement Award; Minor in Mathematics
- U.S. Patent and Trademark Office
- Ph.D., Chemistry, University of California, Berkeley, 2014
- B.S., Biochemistry, University of Oregon, 2008Summa Cum Laude; Departmental Honors; Recipient, 2008 Organic Chemistry Achievement Award; Minor in Mathematics
- U.S. Patent and Trademark Office
Select Publications
- Co-author with H.-C. Xu, M. Chatterjee, A.C. Nairn, P.J. Lombroso, and J.A. Ellman, "Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase," 56(19) Journal of Medicinal Chemistry 7636-50, 2013
- Co-author with J. Xu, M. Chatterjee, J. Brouillette, P. Kurup, J. Kanyo, Y. Zhang, K. Seyb, C. Ononenyi, G.M. Anderson, J. Gresack, G.D. Cuny, M.A. Glicksman, P. Greengard, T.T. Lam, A.C. Nairn, L. Tautz, J.A. Ellman, and P.J. Lombroso, "Inhibitors of the tyrosine phosphatase STEP Reverse Cognitive Deficits in a Mouse Model of Alzheimer's Disease," 12(8) PLoS Biology, 2014
- Co-author with A.C. Nairn, P.J. Lombroso, and J.A. Ellman, "Synthesis of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153) analogs and evaluation as inhibitors of STEP," 25(5) Bioorganic & Medicinal Chemistry Letters 1050-52, 2015
- Co-author with A.W. Buesking and J.A. Ellman, "Asymmetric Synthesis of Amines by the Knochel-Type MgCl2-Enhanced Addition of Benzyl Zinc Reagents to N-tert-Butanesulfinyl Aldimines," 13(5) Organic Letters 964-7, 2011
Select Publications
- Co-author with H.-C. Xu, M. Chatterjee, A.C. Nairn, P.J. Lombroso, and J.A. Ellman, "Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase," 56(19) Journal of Medicinal Chemistry 7636-50, 2013
- Co-author with J. Xu, M. Chatterjee, J. Brouillette, P. Kurup, J. Kanyo, Y. Zhang, K. Seyb, C. Ononenyi, G.M. Anderson, J. Gresack, G.D. Cuny, M.A. Glicksman, P. Greengard, T.T. Lam, A.C. Nairn, L. Tautz, J.A. Ellman, and P.J. Lombroso, "Inhibitors of the tyrosine phosphatase STEP Reverse Cognitive Deficits in a Mouse Model of Alzheimer's Disease," 12(8) PLoS Biology, 2014
- Co-author with A.C. Nairn, P.J. Lombroso, and J.A. Ellman, "Synthesis of 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153) analogs and evaluation as inhibitors of STEP," 25(5) Bioorganic & Medicinal Chemistry Letters 1050-52, 2015
- Co-author with A.W. Buesking and J.A. Ellman, "Asymmetric Synthesis of Amines by the Knochel-Type MgCl2-Enhanced Addition of Benzyl Zinc Reagents to N-tert-Butanesulfinyl Aldimines," 13(5) Organic Letters 964-7, 2011
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