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Mengmeng Zhang
Associate
Patents and Innovations
Boston
mmzhang@wsgr.com

D617-598-7814

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Dr. Mengmeng Zhang is an associate in the Boston office of Wilson Sonsini Goodrich & Rosati, where she is a member of the patents and innovations practice. Her technical expertise spans across a variety of fields, including immuno-oncology, biochemistry, molecular biology, chemical biology, and pharmacogenetics.

Prior to joining the firm, Mengmeng was a research fellow at the Wyss Institute of Harvard University, where she developed DNA-based diagnostic tools for circulating tumor DNA detection and co-founded a start-up company for cancer diagnosis using liquid biopsy. Before joining the Wyss Institute, she was a postdoctoral fellow in Dr. Randy King's laboratory at Harvard Medical School. In this role, she worked on developing imaging-based small molecule inhibitor screening methods for anaphase-promoting complex and studied mechanisms of mitotic exit.

Mengmeng earned her Ph.D. degree in Biochemistry from the University of Texas at Austin. During her doctoral studies, she conducted research on the mechanisms and structures of several key phosphatases involved in the post-translational modification of RNA polymerase II. She also worked on identifying small molecule inhibitors for one of the phosphatases that is involved in neuronal gene silencing. While attending graduate school, she conducted research on genetically manipulating immune cells in the tumor microenvironment for cancer therapy, focusing on macrophages.

Experience

Dr. Mengmeng Zhang is an associate in the Boston office of Wilson Sonsini Goodrich & Rosati, where she is a member of the patents and innovations practice. Her technical expertise spans across a variety of fields, including immuno-oncology, biochemistry, molecular biology, chemical biology, and pharmacogenetics.

Prior to joining the firm, Mengmeng was a research fellow at the Wyss Institute of Harvard University, where she developed DNA-based diagnostic tools for circulating tumor DNA detection and co-founded a start-up company for cancer diagnosis using liquid biopsy. Before joining the Wyss Institute, she was a postdoctoral fellow in Dr. Randy King's laboratory at Harvard Medical School. In this role, she worked on developing imaging-based small molecule inhibitor screening methods for anaphase-promoting complex and studied mechanisms of mitotic exit.

Mengmeng earned her Ph.D. degree in Biochemistry from the University of Texas at Austin. During her doctoral studies, she conducted research on the mechanisms and structures of several key phosphatases involved in the post-translational modification of RNA polymerase II. She also worked on identifying small molecule inhibitors for one of the phosphatases that is involved in neuronal gene silencing. While attending graduate school, she conducted research on genetically manipulating immune cells in the tumor microenvironment for cancer therapy, focusing on macrophages.

Education
  • J.D., Suffolk University Law School, 2022Cum Laude, Intellectual Property Law Concentration with Distinction, Dean’s List
  • Postdoctoral Research Fellowship, Harvard Medical School and Wyss Institute2013-2016
  • Ph.D., Biochemistry, University of Texas at Austin, 2012
  • M.S., Biological Sciences, Clemson University, 2008
  • B.E., Bioengineering, Shanghai Jiao Tong University, China, 2006
Admissions
  • State Bar of Massachusetts
  • U.S. Patent and Trademark Office
Credentials
Education
  • J.D., Suffolk University Law School, 2022Cum Laude, Intellectual Property Law Concentration with Distinction, Dean’s List
  • Postdoctoral Research Fellowship, Harvard Medical School and Wyss Institute2013-2016
  • Ph.D., Biochemistry, University of Texas at Austin, 2012
  • M.S., Biological Sciences, Clemson University, 2008
  • B.E., Bioengineering, Shanghai Jiao Tong University, China, 2006
Admissions
  • State Bar of Massachusetts
  • U.S. Patent and Trademark Office

Select Publications

  • Co-author, "Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase," 9(147) Science Signaling, 2016
  • Co-author, "Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II," 10(10) ACS Chemical Biology 2405-14, 2015
  • Co-author, "Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C," 514(7524) Nature 646-9, 2014
  • Co-author, "Viewing Serine/Threonine Protein Phosphatases through the Eyes of Drug Designers," 280(19) FEBS Journal 4739-60, 2013
  • Co-author, "Structural and kinetic analysis of the prolyl isomerization/phosphorylation cross-talk in the CTD code," 7(8) ACS Chemical Biology 1462-70, 2012
  • Co-author, "A pharmacogenetic study of risperidone on histamine H3 receptor gene (HRH3) in Chinese Han schizophrenia patients," 26(6) Journal of Psychopharmacology 813-8, 2011
  • Co-author, "Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor," 6(5) ACS Chemical Biology 511-9, 2011
  • Co-author, "Crystal Structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue," 434(3) Biochemical Journal 435-44, 2011
  • Co-author, "Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II," Nano Reviews, 2010
  • Co-author, "Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1," 19(5) Protein Science 974-86, 2010
Insights

Select Publications

  • Co-author, "Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase," 9(147) Science Signaling, 2016
  • Co-author, "Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II," 10(10) ACS Chemical Biology 2405-14, 2015
  • Co-author, "Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C," 514(7524) Nature 646-9, 2014
  • Co-author, "Viewing Serine/Threonine Protein Phosphatases through the Eyes of Drug Designers," 280(19) FEBS Journal 4739-60, 2013
  • Co-author, "Structural and kinetic analysis of the prolyl isomerization/phosphorylation cross-talk in the CTD code," 7(8) ACS Chemical Biology 1462-70, 2012
  • Co-author, "A pharmacogenetic study of risperidone on histamine H3 receptor gene (HRH3) in Chinese Han schizophrenia patients," 26(6) Journal of Psychopharmacology 813-8, 2011
  • Co-author, "Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor," 6(5) ACS Chemical Biology 511-9, 2011
  • Co-author, "Crystal Structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue," 434(3) Biochemical Journal 435-44, 2011
  • Co-author, "Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II," Nano Reviews, 2010
  • Co-author, "Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1," 19(5) Protein Science 974-86, 2010

Biological Sciences and Biotechnology

  • Antibody
  • Antigen presentation
  • Biochemical assays
  • Biochemistry
  • Biologics
  • Cancer biology
  • Cancer therapeutics
  • CAR-T cells
  • Cell biology
  • Cell culture products
  • Cell therapy
  • Cellular immunology
  • Immuno-oncology
  • Immunobiology
  • Immunology
  • Molecular biology
  • Molecular genetics
  • PCR
  • Proteomics
  • T and B cell biology
  • T cell biology

Therapeutics and Drug Discovery

  • Gene editing
  • Immunotherapy targets
  • Pharmacogenomics
  • Vaccines

Diagnostics and Medical Devices

  • Diagnostics
  • Point-of-care testing (POCT)

Chemistry and Material Science

  • Protein engineering

Genomics and Data Analysis

  • Next-generation sequencing
  • Sequencing
  • Single-cell sequencing

Miscellaneous

  • Cancer
  • Fluorescence microscopy
  • Infectious diseases
Technical Fluency

Biological Sciences and Biotechnology

  • Antibody
  • Antigen presentation
  • Biochemical assays
  • Biochemistry
  • Biologics
  • Cancer biology
  • Cancer therapeutics
  • CAR-T cells
  • Cell biology
  • Cell culture products
  • Cell therapy
  • Cellular immunology
  • Immuno-oncology
  • Immunobiology
  • Immunology
  • Molecular biology
  • Molecular genetics
  • PCR
  • Proteomics
  • T and B cell biology
  • T cell biology

Therapeutics and Drug Discovery

  • Gene editing
  • Immunotherapy targets
  • Pharmacogenomics
  • Vaccines

Diagnostics and Medical Devices

  • Diagnostics
  • Point-of-care testing (POCT)

Chemistry and Material Science

  • Protein engineering

Genomics and Data Analysis

  • Next-generation sequencing
  • Sequencing
  • Single-cell sequencing

Miscellaneous

  • Cancer
  • Fluorescence microscopy
  • Infectious diseases
Focus Areas
  • Intellectual Property
  • Life Sciences
  • Patents and Innovations
Recent Insights
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On October 22, 2024, AvenCell Therapeutics, a leading clinical-stage cell therapy company focused on advancing both autologous and allogeneic switchable CAR-T cell therapies, announced that it has raised $112 million in Series B financing. The financing was led by global life sciences investor Novo Holdings. New investors F-Prime Capital, Eight Roads Ventures Japan, Piper Heartland Healthcare Capital, and NYBC Ventures also participated in the round alongside founding investor Blackstone Life Sciences. Wilson Sonsini Goodrich & Rosati advised Novo Holdings and F-Prime Capital on the transaction.
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On July 28, 2020, TCR2 Therapeutics Inc., a clinical-stage immunotherapy company with a pipeline of novel T cell therapies for patients suffering from cancer, announced the pricing of an underwritten public offering of 8,000,000 shares of its common stock at a public offering price of $15.50 per share. TCR2 also granted the underwriters a 30-day option to purchase up to an additional 1,200,000 shares of common stock at the public offering price, less the underwriting discounts and commissions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and offering expenses payable by the company, are expected to be $124 million, excluding any exercise of the underwriters’ option to purchase additional shares. All of the shares in the offering are to be sold by TCR2. The offering is expected to close on or about July 31, 2020, subject to customary closing conditions. TCR2 intends to use the net proceeds of the offering to advance its clinical and earlier stage programs and for research and development, working capital, and general corporate purposes.
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