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August Li
Patent Agent
Patents and Innovations
Washington, D.C.
august.li@wsgr.com

D202-973-8884

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T. August Li is a patent agent in the Washington, D.C., office of Wilson Sonsini Goodrich & Rosati, where she is a member of the patents and innovations practice. With extensive interdisciplinary research experience in molecular and clinical pharmacology, and additional focuses in glycobiology, neuroscience, and immunology, August assists clients in preparation and prosecution of patent applications.

Prior to joining the firm, August trained under Dr. Ronald Schnaar at the Johns Hopkins University, where she discovered anti-inflammatory proteoglycans that engage human Siglecs in the esophagus, airways, and brain. She also has studied the roles of gangliosides in glutamate receptor trafficking to understand the seizures and learning disabilities seen in patients with congenital disorders of ganglioside biosynthesis. Her technical expertise spans molecular biology, cell biology, biochemistry, and glycobiology. August obtained her Doctor of Pharmacy at Purdue University, where she gained profound knowledge of pathophysiology, pharmacotherapy, and drug development. 

Experience

T. August Li is a patent agent in the Washington, D.C., office of Wilson Sonsini Goodrich & Rosati, where she is a member of the patents and innovations practice. With extensive interdisciplinary research experience in molecular and clinical pharmacology, and additional focuses in glycobiology, neuroscience, and immunology, August assists clients in preparation and prosecution of patent applications.

Prior to joining the firm, August trained under Dr. Ronald Schnaar at the Johns Hopkins University, where she discovered anti-inflammatory proteoglycans that engage human Siglecs in the esophagus, airways, and brain. She also has studied the roles of gangliosides in glutamate receptor trafficking to understand the seizures and learning disabilities seen in patients with congenital disorders of ganglioside biosynthesis. Her technical expertise spans molecular biology, cell biology, biochemistry, and glycobiology. August obtained her Doctor of Pharmacy at Purdue University, where she gained profound knowledge of pathophysiology, pharmacotherapy, and drug development. 

Education
  • Ph.D., Pharmacology and Molecular Sciences, Johns Hopkins University
  • Doctor of Pharmacy, Purdue University
Admissions
  • U.S. Patent and Trademark Office
Credentials
Education
  • Ph.D., Pharmacology and Molecular Sciences, Johns Hopkins University
  • Doctor of Pharmacy, Purdue University
Admissions
  • U.S. Patent and Trademark Office

Select Publications

  • Lead author with A. Gonzalez-Gil, A.K. Awol, S.J. Ackerman, B.C. Orsburn, and R.L. Schnaar, “Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus,” 34(10) Glycobiology, 2024

  • Co-author with A. Gonzalez-Gil, K. Jean, and R.L. Schnaar, “Human sialoglycan ligands for immune inhibitory Siglecs,” Molecular Aspects of Medicine, 2022
  • Co-author with A. Gonzalez-Gil, R.N. Porell, S.M. Fernandes, E. Maenpaa, T. Li, P.C. Wong, K. Aoki, M. Tiemeyer, Z.J. Yu, B.C. Orsburn, N.N. Bumpus, R.T. Matthews, and R.L. Schnaar, “Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease,” 298(6) J. Biol. Chem. 101960, 2022
  • Lead author with R. Schnaar, “Congenital Disorders of Ganglioside Biosynthesis,” 156 Prog Mol Biol Transl Sci. 63-82, 2018
  • Co-author with A. Gonzalez-Gil, R.N. Porell, S.M. Fernandes, H.E. Tarbox, H.S. Lee, K. Aoki, M. Tiemeyer, J. Kim, and R.L. Schnaar, “Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8,” 20 J Allergy Clin Immunol. 31107-6, 2020
  • Co-author with H. Lee, A. Gonzales-Gil, V. Drake, R.L. Schnaar, and J. Kim, “Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis,” Glycobiology, 2021 
  • Co-author with Y. Wang, S. Tang, K.E. Harvey, A.E. Salyer, E.K. Rantz, M.A. Lill, and G.H. Hockerman, “Molecular Determinants of the Differential Modulation of Cav1.2 and Cav1.3 by Nifedipine and FPL 64176,” 94(3) Mol Pharmacol 973-983, 2018
Insights

Select Publications

  • Lead author with A. Gonzalez-Gil, A.K. Awol, S.J. Ackerman, B.C. Orsburn, and R.L. Schnaar, “Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus,” 34(10) Glycobiology, 2024

  • Co-author with A. Gonzalez-Gil, K. Jean, and R.L. Schnaar, “Human sialoglycan ligands for immune inhibitory Siglecs,” Molecular Aspects of Medicine, 2022
  • Co-author with A. Gonzalez-Gil, R.N. Porell, S.M. Fernandes, E. Maenpaa, T. Li, P.C. Wong, K. Aoki, M. Tiemeyer, Z.J. Yu, B.C. Orsburn, N.N. Bumpus, R.T. Matthews, and R.L. Schnaar, “Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease,” 298(6) J. Biol. Chem. 101960, 2022
  • Lead author with R. Schnaar, “Congenital Disorders of Ganglioside Biosynthesis,” 156 Prog Mol Biol Transl Sci. 63-82, 2018
  • Co-author with A. Gonzalez-Gil, R.N. Porell, S.M. Fernandes, H.E. Tarbox, H.S. Lee, K. Aoki, M. Tiemeyer, J. Kim, and R.L. Schnaar, “Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8,” 20 J Allergy Clin Immunol. 31107-6, 2020
  • Co-author with H. Lee, A. Gonzales-Gil, V. Drake, R.L. Schnaar, and J. Kim, “Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis,” Glycobiology, 2021 
  • Co-author with Y. Wang, S. Tang, K.E. Harvey, A.E. Salyer, E.K. Rantz, M.A. Lill, and G.H. Hockerman, “Molecular Determinants of the Differential Modulation of Cav1.2 and Cav1.3 by Nifedipine and FPL 64176,” 94(3) Mol Pharmacol 973-983, 2018

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Technical Fluency

Biological Sciences and Biotechnology

  • Antibody
  • Antigen presentation
  • Biochemical assays
  • Biochemistry
  • Bioconjugation
  • Biologics
  • Cancer biology
  • Cancer therapeutics
  • CAR-T cells
  • Cell biology
  • Cell culture products
  • Cell therapy
  • Cellular biology
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  • MicroRNA (miRNA) research
  • Molecular biology
  • Molecular genetics
  • Neurobiology
  • PCR
  • T and B cell biology
  • T cell biology
  • T cell immunology
  • Virology

Therapeutics and Drug Discovery

  • Antimicrobial agents
  • Biosimilars
  • CRISPR
  • Drug conjugates
  • Drug conjugates based drug discovery
  • Drug delivery
  • Gene editing
  • Gene therapy
  • Immunotherapy targets
  • Neuropharmacology
  • Peptide therapeutics
  • Pharmacodynamics
  • Pharmacogenomics
  • Pharmacokinetics
  • Pharmacology
  • RNA interference (RNAi)
  • Small molecule synthesis
  • Small molecules
  • Vaccines

Diagnostics and Medical Devices

  • Biomedical devices
  • Diagnostics
  • Medical devices
  • Point-of-care testing (POCT)

Chemistry and Material Science

  • Chemoenzymatic synthesis

Miscellaneous

  • Cancer
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  • Fluorescence microscopy
  • Formulations
  • Infectious diseases
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Recent Insights
Client Highlights
Wilson Sonsini Advises Opus Genetics on IP Matters Related to Acquisition by Ocuphire Pharma
On October 22, 2024, Ocuphire Pharma, Inc., a clinical-stage ophthalmic biopharmaceutical company focused on developing and commercializing therapies for the treatment of patients with retinal and refractive eye disorders, announced the all-stock acquisition of Opus Genetics, Inc., a clinical-stage gene therapy company for inherited retinal diseases (IRDs). The merger creates a transformative biotech company committed to being a leader in the development of gene therapies for the treatment of IRDs. In connection with the merger, the combined company will be renamed Opus Genetics, Inc., effective October 23, 2024, and will trade on Nasdaq under the ticker symbol “IRD” effective October 24, 2024.
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